PLATELETS AND THROMBOPOIESIS The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy
نویسندگان
چکیده
1Department of Hematology, Spirito Santo Hospital, Pescara, Italy; 2Center of Excellence on Aging, G. D’Annunzio University Foundation, Chieti, Italy; 3Department of Biomedical Sciences, University G. D’Annunzio, Chieti, Italy; 4Department of Pharmacology, Catholic University School of Medicine, Rome, Italy; 5Department of Biochemistry, American University of Beirut, Beirut, Lebanon; 6Department of Pathology, Catholic University School of Medicine, Rome, Italy; and 7Department of Drug Sciences, School of Pharmacy, University G. D’Annunzio, Chieti, Italy
منابع مشابه
PLATELETS AND THROMBOPOIESIS Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target
Essential thrombocythemia (ET) is characterized by enhanced platelet generation and thrombotic complications. Oncedaily low-dose aspirin incompletely inhibits platelet thromboxane A2 (TXA2) in the majority of ET patients. In the present study, we investigated the determinants of aspirin-insensitive platelet TXA2 biosynthesis and whether it could be further suppressed by changing the aspirin dos...
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ticulated platelets in ET draws attention to another major mechanism—namely, COX-1 activity in newly released platelets not inhibited by the once-daily low-dose aspirin. This is because of the relatively short half-life of aspirin in plasma. In states with rapid platelet generation, one daily dose of low-dose aspirin may be insufficient because of the immense capacity of bone marrow to accelera...
متن کاملThe use of platelet function assays may help to determine appropriate antiplatelet treatment options in a patient with recurrent stroke on baby aspirin: against.
Patients with ischemic stroke of arterial origin are commonly prescribed aspirin because it has been shown in placebo-controlled trials to reduce the risk of a recurrent stroke and other major vascular events by approximately 13% (95% CI, 6% to 19%).1,2 The mechanism by which aspirin “works” is that, at doses as low as 0.5 mg/kg, it irreversibly inactivates platelet cyclo-oxygenase-1 by at leas...
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